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1

Preparation of Oxime Dual NK1/NK2 Antagonists with Reduced NK3 Affinity.

Gregory A. Reichard, Cheryl A. Grice, Neng-Yang Shih, James Spitler, Sapna Majmundar, Steven D. Wang, Sunil Paliwal, John C. Anthes, John J. Piwinski

Journal:

Année:

2002

Fichier:

PDF, 31 KB

2002

2

Preparation of oxime dual NK1/NK2 antagonists with reduced NK3 affinity

Gregory A Reichard, Cheryl A Grice, Neng-Yang Shih, James Spitler, Sapna Majmundar, Steven D Wang, Sunil Paliwal, John C Anthes, John J Piwinski

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2002

Langue:

english

Fichier:

PDF, 122 KB

english, 2002

3

Total synthesis of lactacystin

Corey, E. J., Reichard, Gregory A.

Journal:

Journal of the American Chemical Society

Année:

1992

Langue:

english

Fichier:

PDF, 253 KB

english, 1992

4

Tafenoquine and NPC-1161B require CYP 2D metabolism for anti-malarial activity: implications for the 8-aminoquinoline class of anti-malarial compounds

Marcsisin, Sean R, Sousa, Jason C, Reichard, Gregory A, Caridha, Diana, Zeng, Qiang, Roncal, Norma, McNulty, Ronan, Careagabarja, Julio, Sciotti, Richard J, Bennett, Jason W, Zottig, Victor E, Deye, G

Journal:

Malaria Journal

Année:

2014

Langue:

english

Fichier:

PDF, 501 KB

english, 2014

5

Isolation of circulating metabolites in drug discovery using high-performance liquid chromatography, and their identification by liquid chromatography coupled with tandem mass spectrometry and nuclear magnetic resonance spectroscopy

Hong Kim, Wenqing Feng, Tze-Ming Chan, Diane Rindgen, Matthew Bryant, Kathleen A. Cox, Yan Xia, Gregory Reichard, Sunil Paliwal, David Hesk, Jairam Palamanda, Ronald E. White, Amin A. Nomeir

Journal:

Journal of Separation Science

Année:

2002

Langue:

english

Fichier:

PDF, 221 KB

english, 2002

6

ChemInform Abstract: The Design and Synthesis of Novel NK1/NK2 Dual Antagonists.

Gregory A. Reichard, Zachary T. Ball, Robert Aslanian, John C. Anthes, Neng-Yang Shih, John J. Piwinski

Journal:

Année:

2001

Fichier:

PDF, 34 KB

2001

7

An efficient approach for the rapid assessment of oral rat exposures for new chemical entities in drug discovery

Hyo-Kyung Han, Nalini Sadagopan, Gregory A. Reichard, Udeni Yapa, Tong Zhu, Andrea Hubbel, Kjell Johnson, Joanne Brodfuehrer

Journal:

Journal of Pharmaceutical Sciences

Année:

2006

Langue:

english

Fichier:

PDF, 216 KB

english, 2006

8

Discovery of a novel, potent and orally active series of γ-lactams as selective NK1 antagonists

Sunil Paliwal, Gregory A. Reichard, Sapna Shah, Michelle Laci Wrobleski, Cheng Wang, Carmine Stengone, Hon-Chung Tsui, Dong Xiao, Ruth A. Duffy, Jean E. Lachowicz, Amin A. Nomeir, Geoffrey B. Varty, N

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2008

Langue:

english

Fichier:

PDF, 189 KB

english, 2008

9

Cyclic urea derivatives as potent NK1 selective antagonists

Ho-Jane Shue, Xiao Chen, Neng-Yang Shih, David J. Blythin, Sunil Paliwal, Ling Lin, Danlin Gu, John H. Schwerdt, Sapna Shah, Gregory A. Reichard, John J. Piwinski, Ruth A. Duffy, Jean E. Lachowicz, Vi

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2005

Langue:

english

Fichier:

PDF, 223 KB

english, 2005

10

Cyclic urea derivatives as potent NK1 selective antagonists. Part II: Effects of fluoro and benzylic methyl substitutions

Ho-Jane Shue, Xiao Chen, John H. Schwerdt, Sunil Paliwal, David J. Blythin, Ling Lin, Danlin Gu, Cheng Wang, Gregory A. Reichard, Hongwu Wang, John J. Piwinski, Ruth A. Duffy, Jean E. Lachowicz, Vicki

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2006

Langue:

english

Fichier:

PDF, 151 KB

english, 2006

11

Discovery of a series of potent, orally active α,α-disubstituted piperidine NK1 antagonists

Dong Xiao, Cheng Wang, Anandan Palani, Hon-Chung Tsui, Gregory Reichard, Sunil Paliwal, Neng-Yang Shih, Robert Aslanian, Ruth Duffy, Jean Lachowicz, Geoffrey Varty, Cynthia Morgan, Fei Liu, Amin Nomei

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2010

Langue:

english

Fichier:

PDF, 1.31 MB

english, 2010

12

Two complementary, diversity-driven asymmetric syntheses of a 2,2-disubstituted piperidine NK1 antagonist

Dong Xiao, Cheng Wang, Anandan Palani, Gregory Reichard, Robert Aslanian, Neng-Yang Shih, Alexei Buevich

Journal:

Tetrahedron: Asymmetry

Année:

2006

Langue:

english

Fichier:

PDF, 123 KB

english, 2006

13

Synthesis of (6R,7S)-lactacystin and 6-deoxylactacystin from a common intermediate

E.J. Corey, Gregory A. Reichard

Journal:

Tetrahedron Letters

Année:

1993

Langue:

english

Fichier:

PDF, 256 KB

english, 1993

14

Studies on the total synthesis of lactacystin. An improved aldol coupling reaction and a β-lactone intermediate in thiol ester formation

E.J. Corey, Gregory A. Reichard, Robert Kania

Journal:

Tetrahedron Letters

Année:

1993

Langue:

english

Fichier:

PDF, 274 KB

english, 1993

15

Enantioselective and practical syntheses of R- and S-fluoxetines

E.J Corey, Gregory A Reichard

Journal:

Tetrahedron Letters

Année:

1989

Langue:

english

Fichier:

PDF, 199 KB

english, 1989

16

(+)-1(S), 5(R), 8(S)-8-phenyl-2-azabicyclo[3.3.0]octan-8-ol n,o-methylboronate (2) and its enantiomer, chiral chemzymes which serve as catalysts for their own enantioselective synthesis

E.J Corey, C.-P Chen, Gregory A Reichard

Journal:

Tetrahedron Letters

Année:

1989

Langue:

english

Fichier:

PDF, 304 KB

english, 1989

17

The asymmetric synthesis of (3R)-N-methyl-2-oxo-[1,4′-bipiperidine]-3-acetamide in quantity

Gregory A. Reichard, James Spitler, Ingrid Mergelsberg, Alan Miller, George Wong, Ramani Raghavan, John Jenkins, Tong Gan, Andrew T. McPhail

Journal:

Tetrahedron: Asymmetry

Année:

2002

Langue:

english

Fichier:

PDF, 153 KB

english, 2002

18

The design and synthesis of novel NK1/NK2 dual antagonists

Gregory A Reichard, Zachary T Ball, Robert Aslanian, John C Anthes, Neng-Yang Shih, John J Piwinski

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2000

Langue:

english

Fichier:

PDF, 188 KB

english, 2000

19

Synthesis and structure–activity relationships of oxime neurokinin antagonists: discovery of potent arylamides

Neng-Yang Shih, Margaret Albanese, John C Anthes, Nicholas I Carruthers, Cheryl A Grice, Ling Lin, Pietro Mangiaracina, Gregory A Reichard, John Schwerdt, Vera Seidl, Shing-Chung Wong, John J Piwinski

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2002

Langue:

english

Fichier:

PDF, 160 KB

english, 2002

20

Structure–Activity relationships of oxime neurokinin antagonists: oxime modifications

Gregory A Reichard, James Spitler, Robert Aslanian, Mwangi wa Mutahi, Neng-Yang Shih, Ling Lin, Pauline C Ting, John C Anthes, John J Piwinski

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2002

Langue:

english

Fichier:

PDF, 117 KB

english, 2002

21

Cyclobutane derivatives as potent NK1 selective antagonists

Michelle Laci Wrobleski, Gregory A. Reichard, Sunil Paliwal, Sapna Shah, Hon-Chung Tsui, Ruth A. Duffy, Jean E. Lachowicz, Cynthia A. Morgan, Geoffrey B. Varty, Neng-Yang Shih

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2006

Langue:

english

Fichier:

PDF, 134 KB

english, 2006

22

Synthesis and x-ray structure of a potent superpositional analog of the enantiomeric forms of fluoxetine

E.J. Corey, Gregory A. Reichard, Sepehr Sarshar

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1993

Langue:

english

Fichier:

PDF, 145 KB

english, 1993

23

Incidence, Risk Factors, and Complications of Postoperative Delirium in Elderly Patients Undergoing Radical Cystectomy

Large, Michael C., Reichard, Chad, Williams, Joshua T.B., Chang, Charles, Prasad, Sandip, Leung, Yiuka, DuBeau, Catherine, Bales, Gregory T., Steinberg, Gary D.

Journal:

Année:

2013

Langue:

english

Fichier:

PDF, 195 KB

english, 2013

24

SARVision Plus by ChemApps SARvision Plus

Reichard, Gregory A.

Journal:

Journal of Chemical Information and Modeling

Année:

2008

Langue:

english

Fichier:

PDF, 35 KB

english, 2008

25

Asymmetric Synthesis of 4,4-Disubstituted-2-Imidazoli-dinones: Potent NK 1 Antagonists

Reichard, Gregory A., Stengone, Carmine, Paliwal, Sunil, Mergelsberg, Ingrid, Majmundar, Sapna, Wang, Cheng, Tiberi, Robert, McPhail, Andrew T., Piwinski, John J., Shih, Neng-Yang

Journal:

Organic Letters

Année:

2003

Langue:

english

Fichier:

PDF, 93 KB

english, 2003

26

A New Magnesium-Catalyzed Doubly Diastereoselective anti -Aldol Reaction Leads to a Highly Efficient Process for the Total Synthesis of Lactacystin in Quantity

Corey, E. J., Li, Weidong, Reichard, Gregory A.

Journal:

Journal of the American Chemical Society

Année:

1998

Langue:

english

Fichier:

PDF, 195 KB

english, 1998

27

Prevalence of Ehrlichia, Borrelia, and Rickettsial Agents in Amblyomma americanum (Acari: Ixodidae) Collected from Nine States

Mixson, Tonya R., Campbell, Scott R., Gill, James S., Ginsberg, Howard S., Reichard, Mason V., Schulze, Terry L., Dasch, Gregory A.

Journal:

Journal of Medical Entomology

Année:

2006

Langue:

english

Fichier:

PDF, 307 KB

english, 2006

28

A β-Lactone Related to Lactacystin Induces Neurite Outgrowth in a Neuroblastoma Cell Line and Inhibits Cell Cycle Progression in an Osteosarcoma Cell Line

Gabriel Fenteany, Robert F. Standaert, Gregory A. Reichard, E. J. Corey and Stuart L. Schreiber

Journal:

Proceedings of the National Academy of Sciences

Année:

1994

Langue:

english

Fichier:

PDF, 1.08 MB

english, 1994

29

Primaquine pharmacology in the context of CYP 2D6 pharmacogenomics: Current state of the art

Marcsisin, Sean R., Reichard, Gregory, Pybus, Brandon S.

Journal:

Pharmacology & Therapeutics

Année:

2016

Langue:

english

Fichier:

PDF, 1.20 MB

english, 2016

30

Differential kinetic profiles and metabolism of primaquine enantiomers by human hepatocytes

Fasinu, Pius S., Avula, Bharathi, Tekwani, Babu L., Nanayakkara, N. P. Dhammika, Wang, Yan-Hong, Bandara Herath, H. M. T., McChesney, James D., Reichard, Gregory A., Marcsisin, Sean R., Elsohly, Mahmo

Journal:

Malaria Journal

Année:

2016

Langue:

english

Fichier:

PDF, 1.27 MB

english, 2016

31

The Lopsidedness of Present‐Day Galaxies: Results from the Sloan Digital Sky Survey

Reichard, Timothy A., Heckman, Timothy M., Rudnick, Gregory, Brinchmann, Jarle, Kauffmann, Guinevere

Journal:

The Astrophysical Journal

Année:

2008

Langue:

english

Fichier:

PDF, 686 KB

english, 2008

32

Single-Dose Primaquine in a Preclinical Model of Glucose-6-Phosphate Dehydrogenase Deficiency: Implications for Use in Malaria Transmission-Blocking Programs

Wickham, Kristina S., Baresel, Paul C., Marcsisin, Sean R., Sousa, Jason, Vuong, Chau T., Reichard, Gregory A., Campo, Brice, Tekwani, Babu L., Walker, Larry A., Rochford, Rosemary

Journal:

Antimicrobial Agents and Chemotherapy

Année:

2016

Langue:

english

Fichier:

PDF, 816 KB

english, 2016

33

Safety, pharmacokinetics, and activity of high-dose ivermectin and chloroquine against the liver-stage of Plasmodium cynomolgi infection in Rhesus Macaques

Vanachayangkul, Pattaraporn, Im-erbsin, Rawiwan, Tungtaeng, Anchalee, Kodchakorn, Chanikarn, Roth, Alison, Adams, John, Chaisatit, Chaiyaporn, Saingam, Piyaporn, Sciotti, Richard J., Reichard, Gregory

Journal:

Antimicrobial Agents and Chemotherapy

Année:

2020

Fichier:

PDF, 776 KB

2020

34

THE LOPSIDEDNESS OF PRESENT-DAY GALAXIES: CONNECTIONS TO THE FORMATION OF STARS, THE CHEMICAL EVOLUTION OF GALAXIES, AND THE GROWTH OF BLACK HOLES

Reichard, Timothy A., Heckman, Timothy M., Rudnick, Gregory, Brinchmann, Jarle, Kauffmann, Guinevere, Wild, Vivienne

Journal:

The Astrophysical Journal

Année:

2009

Fichier:

PDF, 1.34 MB

2009